Role of the adaptins, dynamin-like GTP-ases and Rab proteins in metabolic disorders and various infections

Marcin Kierczak Liliana Surmacz Jolanta Wiejak Elżbieta Wyroba

Opublikowany: 2003-11-15

GICID: 01.3001.0000.3567

Dostępne wersje językowe: en

Wydanie: Postepy Hig Med Dosw 2003; 57 (6)

Abstrakt

Numerous metabolic and genetic diseases are due to mutations in adaptins, dynamin-like GTP-ases or disorders in trafficking machinery mediated by Rab proteins. A great number of pathogenes including viruses (HIV, SIV), bacteria and protozoa use various elements of endocytic/trafficking machinery to get into the host cells and to make their infection successful. Their different strategies are discussed.

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