Abstrakt

Vanadium is a transition metal that has a unique and beneficial effect on both humans and animals. For many years, studies have suggested that vanadium is an essential trace element. Its biological properties are of interest due to its therapeutic potential, including in the treatment of diabetes mellitus. Vanadium deficiencies can lead to a range of pathologies. However, excessive concentration of this metal can cause irreversible damage to various tissues and organs. Vanadium toxicity mainly manifests in gastrointestinal symptoms, including diarrhea, vomiting, and weight reduction. Vanadium also exhibits hepatotoxic and nephrotoxic properties, including glomerulonephritis and pyelonephritis. Vanadium compounds may also lead to partial degeneration of the seminiferous epithelium of the seminiferous tubules in the testes and can affect male fertility. This paper describes the harmful effects of vanadium on the morphology and physiology of both animal and human tissues, including the digestive system, the urinary tract, and the reproductive system. What is more, the following study includes data concerning the correlation between the above-mentioned metal and its influence on fertility and fetus malformations. Additionally, this research identifies the doses of vanadium which lead to pathological alterations becoming visible within tissues. Moreover, this study includes information about the protective efficacy of some substances in view of the toxicity of vanadium.

Przypisy

• 1. Aragón A.M., Altamirano-Lozano M.: Sperm and testicular modifications induced by subchronic treatments with vanadium (IV) in CD-1 mice. Reprod. Toxicol., 2001; 15: 145-151
  Google Scholar
• 2. Barceloux D.G: Vanadium. J. Toxicol. Clin. Toxicol., 1999; 37: 265- 278
  Google Scholar
• 3. Boscolo P., Carmignani M., Volpe A.R., Felaco M., Del Rosso G., Porcelli G., Giuliano G.: Renal toxicity and arterial hypertension in rats chronically exposed to vanadate. Occup. Environ. Med., 1994; 51: 500-503
  Google Scholar
• 4. Boulassel B., Sadeg N., Roussel O., Perrin M., Belhadj-Tahar H.: Fatal poisoning by vanadium. Forensic Sci. Int., 2011; 206: 79-81
  Google Scholar
• 5. Bowen W.H.: Exposure to metal ions and susceptibility to dental caries. J. Dent. Educ., 2001; 65: 1046-1053
  Google Scholar
• 6. Chandra A.K., Ghosh R., Chatterjee A., Sarkar M.: Protection against vanadium-induced testicular toxicity by testosterone propionate in rats. J. Inorg. Biochem., 2007; 101: 944-956
  Google Scholar
• 7. Chandra A.K., Ghosh R., Chatterjee A., Sarkar M.: Vanadiuminduced testicular toxicity and its prevention by oral supplementation of zinc sulphate. Toxicol. Mech. Methods, 2010; 20: 306-315
  Google Scholar
• 8. Cornwall G.A.: Role of posttranslational protein modifications in epididymal sperm maturation and extracellular quality control. Adv. Exp. Med. Biol., 2014; 759: 159-180
  Google Scholar
• 9. D’Cruz O.J., Ghosh P., Uckun F.M.: Spermicidal activity of metallocene complexes containing vanadium (Iv) in humans. Biol. Reprod. 1998; 58: 1515-1526
  Google Scholar
• 10. Da Ros V.G., Munoz M.W., Battistone M.A., Brukman N.G., Carvajal G., Curci L., Gómez-Elias M.D., Cohen D.B., Cuasnicu P.S.: From the epididymis to the egg: participation of CRISP proteins in mammalian fertilization. Asian J. Androl., 2015; 17: 711-715
  Google Scholar
• 11. Deng Y., Cui H., Peng X., Fang J., Wang K., Cui W., Liu X.: Effect of dietary vanadium on cecal tonsil T cell subsets and IL-2 contents in broilers. Biol. Trace Elem. Res., 2011; 144: 647-656
  Google Scholar
• 12. Fortoul T.I., Bizarro-Navares P., Acevedo-Nava S., Pinón-Zárate G., Rodriquez-Lara V., Colin-Barenque L., Mussali-Galante P., Avila- -Casado M.C., Avila-Costa M.R., Saldivar-Osorio L.: Ultrastructural findings in murine seminiferous tubules as a consequence of subchronic vanadium pentoxide inhalation. Reprod. Toxicol., 2007; 23: 588-592
  Google Scholar
• 13. Galli D., Benedetti L., Bongio M., Maliardi V., Silvani G., Ceccarelli G., Ronzoni F., Conte S., Benazzo F., Graziano A., Papaccio G., Sampaolesi M., De Angelis M.G.: In vitr osteoblastic differentiation of human mesenchymal stem cells and human dental pulp stem cells on poly-L-lysine-treated titanium-6-aluminium-4-vanadium. J. Biomed. Mat. Res. A, 2011; 97: 118-126
  Google Scholar
• 14. Heinemann G., Braun S., Overbeck M., Page M., Michel J., Vogt W.: The effect of vanadium-contaminated commercially available albumin solutions on renal tubular function. Clin. Nephrol., 2000; 53: 473-478
  Google Scholar
• 15. Hosseini M.J., Seyedrazi N., Shahraki J., Pourahmad J.: Vanadium induces liver toxicity through reductive activation by glutathione and mitochondrial dysfunction. Adv. Biosci. Biotechnol., 2012; 3: 1096-1103
  Google Scholar
• 16. Imura H., Shimada A., Naota M., Morita T., Togawa M., Hasegawa T., Seko Y.: Vanadium toxicity in mice: possible impairment of lipid metabolizm and mucosal epithelial cell necrosis in the small intestine. Toxicol. Pathol., 2013; 41: 842-856
  Google Scholar
• 17. Korbecki J., Baranowska-Bosiacka I., Gutowska I., Chlubek D.: Biochemical and medical importance of vanadium compounds. Acta Biochim. Pol., 2012; 59: 195-200
  Google Scholar
• 18. Kucera J., Lener J., Mnuková J.: Vanadium levels in urine and cystine levels in fingernails and hair of exposed and normal persons. Biol. Trace Elem. Res., 1994; 43-45: 327-334
  Google Scholar
• 19. Lahav M., Rennert H., Barzilai D.: Inhibition by vanadate of cyclic AMP production in rat corpora lutea incubated in vitro. Life Sci., 1986; 39: 2557-2564
  Google Scholar
• 20. Liu J., Cui H., Liu X., Peng X., Deng J., Zuo Z., Cui W., Deng Y., Wang K.: Dietary high vanadium causes oxidative damage-induced renal and hepatic toxicity in broilers. Biol. Trace Elem. Res., 2012; 145: 189-200
  Google Scholar
• 21. Liu X., Cui H.M., Peng X., Fang J., Cui W., Wu B.: The effect of dietary vanadium on cell cycle and apoptosis of liver in broilers. Biol. Trace Elem Res., 2011; 143: 1508-1515
  Google Scholar
• 22. Marouane W., Soussi A., Murat J.C., Bezzine S., El Feki A.: The protective effect of Malva sylvestris on rat kidney damaged by vanadium. Lipids Health Dis., 2011; 10: 65
  Google Scholar
• 23. Martin S.J., Reutelingsperger C.P., Mcgahon A.J., Rader J.A., Van Schie R.C., LaFace D.M., Green D.R.: Early redistribution of plasma membrane phosphatidylserine in a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med., 1995; 182: 1545-1556
  Google Scholar
• 24. Minoia C., Sabbioni E., Apostoli P., Pietra R., Pozzoli L., Gallorini M., Nicolaou G., Alessio L., Capodaglio E.: Trace element reference values in tissues from inhibitants of the European Community. I. A study of 46 elements in urine, blood and serum of Italian subjects. Sci. Total Environ, 1990; 95: 89-105
  Google Scholar
• 25. Morgan A.M., El-Tawil O.S.: Effects of ammonium metavanadate on fertility and reproductive performance of adult male and female rats. Pharmacol. Res., 2003; 47: 75-85
  Google Scholar
• 26. Mruk D.D., Cheng C.Y.: Sertoli-Sertoli and Sertoli–germ cell interactions and their significance in germ cell movement in the seminiferous epithelium during spermatogenesis. Endocr. Rev., 2004; 25: 747-806
  Google Scholar
• 27. Olaolorun F.A., Obasa A.A., Balogun H.A., Aina O.O., Olopade J.O.: Lactational vitamin E protects against the histotoxic effects of systemically administered vanadium in neonatal rats. Niger J. Physiol. Sci., 2014; 29: 125-129
  Google Scholar
• 28. Pyttel S., Nimptsch A., Böttger J., Zschörnig K., Jakop U., Wegener J., Müller K., Paasch U., Schiller J.: Changes of murine sperm phospholipid composition during epididymal maturation determined by MALDI-TOF mass spectrometry. Theriogenology, 2014; 82: 396-402
  Google Scholar
• 29. Rodriguez-Lara V., Morales-Rivero A., Rivera-Cambas A.M., Fortoul T.I.: Vanadium inhalation induces actin changes in mice testicular cells. Toxicol. Ind. Health, 2016; 32: 367-374
  Google Scholar
• 30. Roy S., Majumdar S., Singh A.K., Ghosh B., Ghosh N., Manna S., Chakraborty T., Mallick S.: Synthesis, characterization, antioxidant status, and toxicity study of vanadium-rutin complex in Balb/c mice. Biol. Trace Elem. Res., 2015; 166: 183-200
  Google Scholar
• 31. Sarsebekov E.K., Dzharbusynov B.U., Doskeeva R.A.: The nephrotoxic action of heavy crude with a high vanadium content and of its refinery products. Urol. Nefrol., 1994; 3: 35-36
  Google Scholar
• 32. Seńczuk W.: Toksykologia. Wydawnictwo Lekarskie PZWL, Warszawa 1999
  Google Scholar
• 33. Shrivastava S., Jadon A., Shukla S.: Effect of tiron and its combination with nutritional supplements against vanadium intoxication in female albino rats. J. Toxicol. Sci., 2007; 32: 185-192
  Google Scholar
• 34. Shrivastava S., Joshi D., Bhadauria M., Shukla S., Mathur R.: Cotherapy of tiron and selenium against vanadium induced toxic effects in lactating rats. Iran. J. Reprod. Med., 2011; 9: 229-238
  Google Scholar
• 35. Stohs S.J., Bagchi D.: Oxidative mechanisms in the toxicity of metal ions. Free Radic. Biol. Med.,1995; 18: 321-336
  Google Scholar
• 36. Sullivan R.: Epididymosomes: a heterogenous population of microvesicles with multiple functions in sperm maturation and storage. Asian J. Androl., 2015; 17: 726-729
  Google Scholar
• 37. Underwood E.: Trace elements in human and animal nutrition. Academic Press, New York, 1971
  Google Scholar
• 38. Urban J., Antonowicz- Juchniewicz J., Andrzejak R.: Wanad – zagrożenia i nadzieje. Med. Pracy, 2001; 52: 125-133
  Google Scholar
• 39. Vijava Bharahi B., Jaya Prakash G., Krishna K.M., Ravi Krishna C.H., Sivanarayana T., Madan K., Rama Raju G.A., Annapurna A.: Protective effect of alpha glucosyl hesperidin (G-hesperidin) on chronic vanadium induced testicular toxicity and sperm nuclear DNA damage in male Sprague Dawley rats. Andrologia, 2015; 47: 568-578
  Google Scholar
• 40. Wang J.P., Cui R.Y., Zhang K.Y., Ding X.M., Luo Y.H., Bai S.P., Zeng Q.F., Xuan Y., Su Z.W.: High fat diet increased renal and hepatic oxidative stress induced by vanadium of Wistar rats. Biol. Trace Elem. Res., 2016; 170: 415-423
  Google Scholar
• 41. Wang K., Cui H., Deng Y., Peng X.I., Zuo Z., Fang J., Deng J., Cui W., Wu B.: Effect of dietary vanadium on intestinal microbiota in broilers. Biol. Trace Elem. Res., 2012; 149: 212-218
  Google Scholar
• 42. Yilmaz-Ozden T., Kurt-Sirin O., Tunali S., Akev N., Can A., Yanardag R.: Ameliorative effect of vanadium on oxidative stress in stomach tissue of diabetic rats. Bosn. J. Basic Med. Sci., 2014; 14: 105-109
  Google Scholar

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