ARTYKUŁ PRZEGLĄDOWY
Zaburzenia równowagi między komórkami Th17 i Treg we krwi obwodowej chorych na toczeń rumieniowaty układowy z niską aktywnością choroby
Magdalena Szmyrka-Kaczmarek 1 , Agata Kosmaczewska 2 , Lidia Ciszak 2 , Aleksandra Szteblich 2 , Piotr Wiland 11. Department of Rheumatology and Internal Diseases, Wroclaw Medical University, Poland
2. Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw
Opublikowany: 2014-01-02
DOI: 10.5604/17322693.1111127
GICID: 01.3001.0003.1262
Dostępne wersje językowe: pl en
Wydanie: Postepy Hig Med Dosw 2014; 68 : 893-898
Abstrakt
Przypisy
- 1. Alunno A., Bartoloni E., Bistoni O., Nocentini G., Ronchetti S., CaterbiS., Valentini V., Riccardi C., Gerli R.: Balance between regulatoryT and Th17 cells in systemic lupus erythematosus: the old and thenew. Clin. Dev. Immunol., 2012; 2012: 823085
Google Scholar - 2. Alunno A., Bistoni O., Bartoloni E., Caterbi S., Bigerna B., TabarriniA., Mannucci R., Falini B., Gerli R.: IL-17 producing CD4-CD8- Tcells are expanded in the peripheral blood, infiltrate salivary glandsand are resistant to corticoids in patient with primary Sjögren’ssyndrome. Ann. Rheum. Dis., 2013; 72: 286-292
Google Scholar - 3. Doreau A., Belot A., Bastid J., Riche B., Trescol-Biemont M.C.,Ranchin B., Fabien N., Cochat P., Pouteil-Noble C., Trolliet P., DurieuI., Tebib J., Kassai B., Ansieau S., Puisieux A., Eliaou J.F., BonnefoyBérardN.: Interleukin 17 acts in synergy with B cell activating factorto influence B cell biology and the pathophysiology of systemiclupus erythematosus. Nat. Immunol., 2009; 10: 778-785
Google Scholar - 4. Flores-Borja F., Jury E.C., Mauri C., Ehrenstein M.R.: Defects inCTLA-4 are associated with abnormal regulatory T cell function inrheumatoid arthritis. Proc. Natl. Acad. Sci. USA, 2008; 105: 19396-19401
Google Scholar - 5. Hsu HC., Yang P., Wang J. Wu Q., Myers R., Chen J., Yi J., GuentertT., Tousson A., Stanus A.L., Le T.V., Lorenz R.G., Xu H., Kolls J.K.,Carter R.H., Chaplin D.D., Williams R.W., Mountz J.D.: Interleukin17-producing T helper cells and interleukin 17 orchestrate autoreactivegerminal center development in autoimmune BDX2 mice.Nat. Immunol., 2008; 9: 166-175
Google Scholar - 6. Kawashima M., Miossec P.: mRNA quantification of T-bet, GATA-3,IFN-γ, and IL-4 shows a defective Th1 immune response in the peripheralblood from rheumatoid arthritis patients: link with diseaseactivity. J. Clin. Immunol., 2005; 25: 209-214
Google Scholar - 7. Kelchtermans H., De Klerck B., Mitera T., Van Balen M., BullensD., Billiau A., Leclercq G., Matthys P: Defective CD4+CD25+ regulatoryT cell functioning in collagen-induced arthritis: an important factorin pathogenesis, counter-regulated by endogenous IFN-γ. ArthritisRes. Ther. 2005; 7: R402-R415
Google Scholar - 8. Kosmaczewska A., Swierkot J., Ciszak L., Szteblich A., ChrobakA., Karabon L., Partyka A., Szechiński J., Wiland P., Frydecka I.: Patientswith the most advanced rheumatoid arthritis remain withTh1 systemic defects after TNF inhibitors treatment despite clinicalimprovement. Rheumatol. Int., 2014; 34: 243-253
Google Scholar - 9. Kuhn A., Beissert S., Krammer P.H.: CD4+CD25+ regulatory T cells inhuman lupus erythematosus. Arch. Dermatol. Res., 2009; 301: 71-81
Google Scholar - 10. La Cava A.: Regulatory cells in SLE. In: Dubois Lupus Erythematosusand Related Syndromes, Ed.: D.A. Wallace, B.H. Hahn, ElsevierSaunders, Philadelphia 2013, 104-114
Google Scholar - 11. Ma J., Yu J., Tao X., Cai L., Wang J., Zheng S.G.: The imbalancebetween regulatory and IL-17 secreting CD4+ cells in lupus patients.Clin. Rheumatol., 2010; 29: 1251-1258
Google Scholar - 12. Setoguchi R., Hori S., Takahashi T., Sakaguchi S.: Homeostaticmaintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin(IL)-2 and induction of autoimmune disease by IL-2 neutralization.J. Exp. Med., 2005; 201: 723-735
Google Scholar - 13. Shah K., Lee W.W., Lee S.H., Kim S.H., Kang S.W., Craft J., Kang I.:Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus.Arthritis Res. Ther., 2010; 12: R53
Google Scholar - 14. Shin M.S., Lee N., Kang I.: Effector T-cell subsets in systemiclupus erythematosus: update focusing on Th17 cells. Curr. Opin.Rheumatol., 2011; 23: 444-448
Google Scholar - 15. Venigalla R.K., Tretter T., Krienke S., Max R., Eckstein V., Blank N.,Fiehn C., Ho A.D., Lorenz H.M.: Reduced CD4+,CD25- T cell sensitivityto the suppressive function of CD4+,CD25high,CD127-/low regulatory Tcells in patients with active systemic lupus erythematosus. ArthritisRheum., 2008; 58: 2120-2130
Google Scholar - 16. Wing K, Sakaguchi S.: Regulatory T cells. In: Clinical Immunology.Principles and Practice. Third Edition. Edited by Rich RR. MosbyElsevier 2008; 249-258
Google Scholar - 17. Xing Q., Wang B., Su H., Cui J., Li J.: Elevated Th17 cells are accompaniedby FoxP3+ Treg cells decrease in patients with lupusnephritis. Rheumatol. Int., 2012; 32: 949-958
Google Scholar - 18. Yang J., Chu Y., Yang X., Gao D., Zhu L., Yang X., Wan L., Li M.:Th17 and natural Treg cell population dynamics in systemic lupuserythematosus. Arthritis Rheum., 2009; 60: 1472-1483
Google Scholar - 19. Zhang Z., Kyttaris V.C., Tsokos G.C.: The role of IL-23/IL-17 axisin lupus nephritis. J. Immunol., 2009; 183: 3160-3169
Google Scholar